Loss of melatonin daily rhythmicity is asociated with delirium development in hospitalized older adults
نویسندگان
چکیده
Delirium is associated with circadian rhythm disruption. In this study we have explored whether circadian variation of melatonin is an indicator for delirium. Melatonin levels were determined from the first day of hospitalization and up to three days after the onset of delirium. Patients who did not developed delirium exhibited a daily melatonin rhythm, while in patients that developed delirium, the melatonin rhythm was lost and mean melatonin levels were found decreased as early as three days before the diagnosis of delirium, indicating that on arrival to the hospital circadian melatonin disruption can be used as an indicator of delirium.
منابع مشابه
Evaluation of Delirium-Related Rates and Factors in the Elderly Admitted to Selected Teaching Hospitals in Tehran, Iran in 2020-2021
Background and Purpose: Delirium is an acute and fluctuating change in the patient’s mental state associated with decreased alertness and attention deficit disorder that occurs abruptly. This study aimed to investigate the prevalence of delirium-related factors in older adults hospitalized in selected teaching hospitals in Tehran, Iran. Methods: The present study is a cross-sectional analysis ...
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